Anyone else remember Welcome to the NHK? One of the first animes I can recall that properly delved into the mental health crisis that was becoming (and still is) prevalent throughout Japan. It covered it all; from suicide, depression, social isolation, to even the roping in of desperate people into pyramid schemes. I originally watched it back when I was 14 but the anime has really stuck to me over the years and how it to braved touchy subject matter.
View: https://www.youtube.com/watch?v=hHs5AjAvFoA